Prof. Dr. Ahmet Rasim Küçükusta

Dikkat: Yazının sonunda ek var!

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Batı Dünyasında total enerji alımının yüzde 8-10’ unu linoleik asit, bitkisel yağlarda bulunan omega 6 yağ asitleri oluşturuyor.

Omega 6 linoleik asit merada otlayan hayvan ürünlerinde bulunan konjuge linoleik asit ile karıştırılmamalıdır.

Deri altındaki yağ dokusunda linoleik asit konsantrasyonlarının 1959’ dan 2008’ e 2.5 misli arttığı belirlenmiştir.

Yağlı dokudaki linoleik asit miktarı yağ alımının güvenilir bir işaretidir çünkü linoleiak asidin yağlı dokulardaki yarı ömrü 2 sene kadardır.

Yağ dokularında lineleik asitteki artışla diyabet, obezite ve astım prevalansındaki artış birbirine paraleldir.

Omega 6 yağ çoklu doymamış linoleik asit oksidatif stresi, LDL’ nin oksidasyonunu, kronik düşük dereceli enflamasyonu ve aterosklerozu teşvik eder ve koroner kalp hastalıklarına sebep olan en önemli beslenme faktörüdür.

Bunun bilhassa sıklıkla bitkisel yağ olarak bilinen endüstriyel tohum yağları şeklinde tüketilmesi zararlıdır.

Gelelim neticeye

Kalp damar hastalıklarına yol açıyor diye yasaklanan hayvansal doymuş yağlar yerine tavsiye edilen bitkisel tohum yağlar/margarinlerin kalp krizi ve felçlerin temel sebebi olduğu ispatlanmıştır.

Bitkisel yağların ve margarinlerin zerresi bile ağza alınmamalıdır.

Kaynak: https://openheart.bmj.com/content/openhrt/5/2/e000898.full.pdf

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EK 1 (15.9.2022): “Soya proteini diyeti, C. difficile enfeksiyonuna duyarlılığı artırıyor.

Clostridioides difficile causes nosocomial antibiotic-associated diarrhea on a global scale. Susceptibility to C. difficile infection (CDI) is influenced by the composition and metabolism of gut microbiota, which in turn are affected by diet. However, the mechanism underlying the interplay between diet and gut microbiota that modulates susceptibility to CDI remains unclear. Here, we show that a soy protein diet increases the mortality of antibiotic-treated, C. difficile-infected mice while also enhancing the intestinal levels of amino acids (aas) and relative abundance of Lactobacillus genus. Indeed, Ligilactobacillus murinus-mediated fermentation of soy protein results in the generation of aas, thereby promoting C. difficile growth, and the process involves the anchored cell wall proteinase PrtP. Thus, mutual interaction between dietary protein and the gut microbiota is a critical factor affecting host susceptibility to CDI, suggesting that dietary protein sources can be an important determinant in controlling the disease.

Makale: Dietary-protein sources modulate host susceptibility to Clostridioides difficile infection through the gut microbiota

Kaynak: https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01160-3

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EK 2 (5.8.2023): Inflammatory bowel disease (IBD) is a multifactorial disease with increasing incidence in the U.S. suggesting that environmental factors, including diet, are involved. It has been suggested that excessive consumption of linoleic acid (LA, C18:2 omega-6), which must be obtained from the diet, may promote the development of IBD in humans. To demonstrate a causal link between LA and IBD, we show that a high fat diet (HFD) based on soybean oil (SO), which is comprised of ~55% LA, increases susceptibility to colitis in several models, including IBD-susceptible IL10 knockout mice. This effect was not observed with low-LA HFDs derived from genetically modified soybean oil or olive oil. The conventional SO HFD causes classical IBD symptoms including immune dysfunction, increased intestinal epithelial barrier permeability, and disruption of the balance of isoforms from the IBD susceptibility gene Hepatocyte Nuclear Factor 4α (HNF4α). The SO HFD causes gut dysbiosis, including increased abundance of an endogenous adherent invasive Escherichia coli (AIEC), which can use LA as a carbon source. Metabolomic analysis shows that in the mouse gut, even in the absence of bacteria, the presence of soybean oil increases levels of LA, oxylipins and prostaglandins. Many compounds in the endocannabinoid system, which are protective against IBD, are decreased by SO both in vivo and in vitro. These results indicate that a high LA diet increases susceptibility to colitis via microbial and host-initiated pathways involving alterations in the balance of bioactive metabolites of omega-6 and omega-3 polyunsaturated fatty acids, as well as HNF4α isoforms.

Kaynak: https://www.tandfonline.com/doi/full/10.1080/19490976.2023.2229945

Makale: Diet high in linoleic acid dysregulates the intestinal endocannabinoid system and increases susceptibility to colitis in Mice

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Yazı için 2 yorum yapılmış:

1. İhsan dedi ki:

   01 Ekim 2018, 18:28

   tereğaından zeytinyağından başka başka yağ tanımam yumurtadan şaşmam

2. Halil dedi ki:

   02 Ekim 2022, 20:07

   Keten tohumu çörek otu yağları dahilmi hocam

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